Buphthalmos over Three Generations.

Case Reports Case 1, a female child (IV, 3 in Pedigree) born on December 23, 1958, was noticed to have opaque corneae, of sufficient degree to prevent any estimate of the size of the pupils. There was corneal oedema but no appreciable abnormality of the corneal diameter. In the course of a few days the cornea of each eye had become obviously enlarged and a definite buphthalmos had become established. The father (III, 3) informed me that he suffered from buphthalmos, and that his father (II, 2) also had the same condition, and I have since been able to examine them both. Case 2 (III, 3) was first seen by an ophthalmic surgeon in March, 1942, at the age of 15. Both eyes then showed definite buphthalmos with both discs pale and cupped. He has had treatment and now shows a symmetrical condition with a corneal diameter of 14 mm. The visual acuity in the right eye is 6/6; in the left eye it is 6/60. Both optic discs are pale and cupped. During the last 2 months the left eye has developed a high tension with corneal oedema and a further drainage operation has been necessary.